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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Scopolamine
supplement:
Oxiracetam
Research Papers that Mention the Interaction
“The effect of the SC injection of 0.2 mg/kg scopolamine on the efficiency of responding was antagonized by the IP administration of 30 mg/kg oxiracetam , while the effect on running time induced by the same dose of scopolamine was not.”
Oxiracetam antagonizes the disruptive effects of scopolamine on memory in the radial maze“By contrast, oxiracetam attenuated the effect of scopolamine in the hippocampus, frontal cortex and striatum but not in the amygdala.”
“Experiment 2: Oxiracetam administered at doses of 3, 10 and 30 mg/kg immediately after the acquisition session prevented the scopolamine induced prolongation of the transfer latency.”
“ Scopolamine also prevented the increase of particulate PKC elicited by oxiracetam in vitro.”
“Interactive effects in the learning situation, but not in a test of general activity, were also found when oxiracetam was combined with the anticholinergic agent scopolamine.”
“ Oxiracetam , aniracetam and pyroglutamic acid prevent brain acetylcholine decrease and amnesia induced by scopolamine.”
“ Oxiracetam (50 and 100 mg/kg IP) administered 30 min before scopolamine reduced the scopolamine-induced amnesic effect and decrease in acetylcholine level in the cortex and hippocampus, but not in the striatum.”
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