supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Addition of sarcosine enhanced the urea-water structure and urea-water lifetime indicated an increase in the solvation of urea.”
“ Sarcosine is one of the most important protecting osmolytes which is also known to counteract the denaturing effect of urea.”
“These findings suggest that sarcosine indirectly stabilizes protein by enhancing water-water structure thus decreasing the hydrophobic effect and counteracts the effect of urea by increasing the solvation of urea and directly interacting with it leaving urea less available to interact with protein.”
Structure and effect of sarcosine on water and urea by using molecular dynamics simulations: Implications in protein stabilization.“The deleterious effect of urea on proteins has been counteracted by methylamines (osmolytes), such as trimethylamine N-oxide (TMAO), betaine, and sarcosine.”
“The experimental results revealed that the naturally occurring osmolytes TMAO, betaine, and sarcosine strongly counteracted the urea actions on alpha-chymotrypsin.”
“Protein stabilization by sarcosine eliminated the effect of urea and GdmCl on VDAC insertion.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback