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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Sarcosine and Antipsychotic Agents

Research Papers that Mention the Interaction

Clinical trials have shown that agents that directly or indirectly enhance the function of the NMDA receptor at its glycine modulatory site (GMS) reduce negative symptoms and in the case of D-serine and sarcosine improve cognition and reduce positive symptoms in schizophrenic subjects receiving concurrent anti-psychotic medications.
Neurotoxicity Research  •  2009  |  View Paper
Add-on sarcosine combined with first- and second-generation antipsychotics , except clozapine, had a positive effect.
Journal of psychopharmacology  •  2020  |  View Paper
AIM Finding a relationship between schizophrenia symptoms severity and initial level of BDNF and its changes during augmentation of antipsychotic treatment with sarcosine.
Psychiatry Research  •  2016  |  View Paper
Aim: Find changes in matrix metallopeptidase-9 (MMP-9) levels during augmentation of antipsychotic treatment with sarcosine and a relationship between schizophrenia symptoms severity and initial level of MMP-9.
International journal of molecular sciences  •  2016  |  View Paper
We describe here the second case report where sarcosine induced important affect changes when added to antidepressive and antipsychotic treatment , which supports the hypothesis of clinically important glutamate–serotonin interaction.
Neuropsychiatric disease and treatment  •  2015  |  View Paper