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“Clinical trials have shown that agents that directly or indirectly enhance the function of the NMDA receptor at its glycine modulatory site (GMS) reduce negative symptoms and in the case of D-serine and sarcosine improve cognition and reduce positive symptoms in schizophrenic subjects receiving concurrent anti-psychotic medications.”
“AIM Finding a relationship between schizophrenia symptoms severity and initial level of BDNF and its changes during augmentation of antipsychotic treatment with sarcosine.”
“Aim: Find changes in matrix metallopeptidase-9 (MMP-9) levels during augmentation of antipsychotic treatment with sarcosine and a relationship between schizophrenia symptoms severity and initial level of MMP-9.”
International journal of molecular sciences • 2016 | View Paper
“We describe here the second case report where sarcosine induced important affect changes when added to antidepressive and antipsychotic treatment , which supports the hypothesis of clinically important glutamate–serotonin interaction.”