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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Sapropterin
drug:
Tetrahydrobiopterin
Research Papers that Mention the Interaction
“ Sapropterin can reduce phenylalanine (Phe) levels in tetrahydrobiopterin (BH4)-responsive patients, potentially preventing the intellectual impairment caused by elevated Phe levels.”
Long-term preservation of intellectual functioning in sapropterin-treated infants and young children with phenylketonuria: A seven-year analysis.“Sapropterin dihydrochloride sapropterin ) lowers blood Phe in tetrahydrobiopterin ( BH4 ) responsive patients with PKU, in conjunction with a Phe-restricted diet, but clinical evidence supporting its use during pregnancy is limited.”
“Plasma concentrations of BH4 were significantly elevated 3 h after ingestion of sapropterin (0 h: 19.1 ± 2 pmol/ml vs. 3 h: 43.8 ± 3 pmol/ml; P < 0.001).”
“Plasma BH4 was elevated 3 h after ingestion of sapropterin (43.8 ± 3 vs. 19.1 ± 2 pmol/ml; P < 0.001).”
“Treatment with sapropterin resulted in clinically significant and sustained reductions in blood Phe concentrations and increased dietary Phe tolerance in well-designed clinical studies in PKU patients who responded to BH4.”
“Supplementation of BH4 either by intraperitoneal administration of sepiapterin or of 6RBH4 ( (6R)-l-erythro-5,6,7,8-tetrahydrobiopterin ) increased the BH4 content in the intestinal lumen with a slight delay after the rise of blood BH4.”
Tetrahydrobiopterin in intestinal lumen: Its absorption and secretion in the small intestine and the elimination in the large intestine
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