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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“A lack of voltage dependence on the reduction of the peak currents induced by ACh also suggests that Rg(2) does not act as …. The results indicate that Rg(2) acts specifically on heteromeric human nAChRs modulating their desensitization and suggest a possible mechanism by which this saponin … ginseng.”
Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors.“The hypotensive effect induced by crude saponin of KRG reached maximum at 2-4 min and slowly recovered after 20 min to the initial level in both groups.”
“The antiproliferative activity of ginseng has been increased after enzymatic processing of ginseng saponin , which may result in the accumulation of minor saponins, such as Rh2, Rg3, compound K and protopanaxatriol type (PPT) in modified regular ginseng extract (MRGX).”
“In this study, we found that the antiproliferative activity of ginseng was increased after enzymatic processing of ginseng saponin (50% inhibitory concentration, >70 μg/ml).”
“A significant relaxant effect of ginseng saponin was observed from 10–3M, and ginseng saponin significantly relaxed urethra strips by 50.2 ± 20.26% at 10–2M.”
The Relaxant Effect of Ginseng Saponin on the Bladder and Prostatic Urethra: An in vitro and in vivo Study“Taken together, our present results indicated that the inhibitory effects of red ginseng saponin on P450 enzymes may have a critical role in CCl4-induced lipid peroxidation in rat liver microsomes and that the mechanism of hepatoprotection by red ginseng saponin may be distinct from that of silymarin.”
“A high dose of ginseng saponin significantly decreased the thymus weight, although ginseng saponin and a low dose of adrenocorticotropin (ACTH) induced insignificant hypertrophy of the adrenals.”
“ Ginseng saponin evoked a significant increase in the relative thickness of the adrenal cortex.”
“Maximum decrease in the enzyme activity was observed 2 hr after the administration of the ginseng saponin , and it was found that this response depended on the amount of fraction 5 administered to rats.”
“In this study, we found that the antiproliferative activity of ginseng increased after enzymatic processing of ginseng saponin (50% inhibitory concentration [IC50], >30 μg/mL), which may be the result of the accumulation of minor saponins, such as Rh1, Rg3, compound K, and PPT constituents in ginseng saponin.”
Identification of Target Genes Involved in the Antiproliferative Effect of Enzyme-Modified Ginseng Extract in HepG2 Hepatocarcinoma Cell“ Extruded red ginseng showed higher crude saponin contents (6.72~7.18%) than raw red ginseng (5.50%).”
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