Possible Interaction: Salmon Calcitonin and Calcium Supplement

“In all the subjects, rectal administration of 100 IU of SMC induced falls in both plasma total calcium and whole blood ionized calcium: similar levels were observed after intramuscular injection of 50 IU of SMC.”

“Along with … secretory effect SCT … calcium and P absorption by 58% and 62% respectively, without any significant fall in the serum levels of calcium or P. The jejunal response to SCT was reproduced twice in a hypoparathyroid subject showing that endogenous parathyroid hormone was not involved in this effect.”

“It is concluded that SCT induces a net secretion of water and ions while simultaneously reducing calcium and P absorption.”

“The excreted fractions of filtered phosphate—(UV)(P × GFR) · PO 4 —and sodium—(UV)(P × GFR) · Na—and the urinary excretions of calcium (UV Ca ) and magnesium (UV Mg ) increased sharply during the intravenous administration of SCT and in the first following hour.”

“In a study of 164 elderly postmeno-pausal women with “moderate” osteoporosis, those who received intranasal salcatonin 50, 100 or 200 IU/day plus calcium supplements for 2 years had a statistically significant reduction in fracture rate to approximately one-third that of women who received calcium supplements only.”

“Studies in humans demonstrated that single-dose intranasal administration of salcatonin 50 to 400IU reduced bone resorption and increased urinary excretion of calcium , phosphate and sodium.”

“ sCT suppositories were demonstrated to inhibit post-oophorectomy calcium loss , and tolerability was good.”

“Their titer varied from 0.8×10(-9) to 30×10(-9) M/…) to 4.2×10(9) L/M. Intravenous injection of 1 IU/kg SCT … ionized serum calcium (Ca2+) after 30 minutes (mean±SD:-9±0.6%) and …%), with a maximum after 120 minutes (-22.6±2%).”

“Bolus s. c. … pharmacologic dose of sCT (140 IU/kg) … decreased plasma calcium and phosphorus, and suppressed SIT from 1 to 8 h for plasma calcium and phosphorus or 20 h … maximal effects were seen at 5 h, between 2 and 8 h, and between 1 and 5 h).”

“In the presence of inorganic phosphate SCT accelerates the calcium induced oxygen rate consumption, shortens the stimulated respiration time and diminishes the amounts of O2 consumed.”

“The infusion of SCT with calcium to thyroidectomized rats partially prevented the rise in both plasma calcium and phosphate values.”