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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Salicylic Acid
supplement:
Vitamin K
Research Papers that Mention the Interaction
“An increased level of GSH was observed after menadione pretreatment; this increase was blocked by salicylate , thereby linking the GSH increase to activation of NF-kappaB by menadione.”
“ Salicylate prevented the activation of NF-kappaB by menadione , and under these conditions, salicylate potentiated the cytotoxicity of menadione or H2O2.”
Menadione cytotoxicity to Hep G2 cells and protection by activation of nuclear factor-kappaB.“Furthermore, phylloquinone biosynthetic intermediates create crucial metabolic branch-points with other plastid-synthesized metabolites such as chlorophylls, tocopherols and salicylate.”
“ Salicylate antagonizes the vitamin K‐dependent biosynthesis of clotting factors in the rat and produces an elevation of the ratio of vitamin K epoxide to vitamin K in the liver.”
Indirect inhibition of vitamin K epoxide reduction by salicylate“Although some interaction between salicylate and vitamin K was apparent from these experiments, the results from vitamin K-deficient rat liver donors were quite different from those containing salicylate.”
“The inhibitory effect of salicylate was prevented by pretreatment of rat liver donors with supplemental vitamin K injected 24 hours before sacrifice.”
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