Possible Interaction: Salicylic Acid and Vitamin C

“Recent experiments indicate that there is a competition for binding sites on proteins between vitamin C and salicylate and between dicoumarol and vitamin K. Usually a drug exerts a "devitaminizing" action with respect to only one vitamin.”

“ Ascorbic acid (0.5-3.0 mM) induced many-fold increases in SA hydroxylation in a dose-dependent manner in both types of cells.”

“Namely, Blanchard and coworkers(1), Hetzel and Hine(2) and Cronin and King(3) studied specific effect of salicylates … adrenal-pituitary system by using the ascorbic acid content of rat adrenals as indicator, and found that the salicylate … ascorbic acid content considerably in normal rats … not in hypophysectomized ones.”

“Application of moderate concentrations of SA and Vit C markedly reduced the SO2-induced elevation of TBARS levels, with 5.5 mg/kg SA or 200 mg/kg Vit C being most effective.”

“In the pulp tissue, SA treatment increased ascorbic acid and total sugar contents, and MeJA immersions enhanced bioactive compound and antioxidant enzyme activities than SA immersion.”

“When a neutral solution of thymidine and ascorbic acid was irradiated with UV light of wavelength longer than 300 nm in the presence of salicylic acid as a photosensitizer, six product peaks appeared in an HPLC chromatogram in addition to small amounts of thymidine dimers.”

“Results indicated that SA can effectively regulate the accumulation of AsA , especially in ‘Jinpeng-1’.”