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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Salicylic Acid
supplement:
Tryptophan
Research Papers that Mention the Interaction
“2 The elevation of brain tryptophan concentration by sodium salicylate (0.5 mg/kg) was caused by inhibition of liver pyrrolase activity, whereas that by doses of the drug of 50 mg/kg and above was achieved mainly by tryptophan displacement.”
MECHANISMS OF ELEVATION OF RAT BRAIN TRYPTOPHAN CONCENTRATION BY VARIOUS DOSES OF SALICYLATE“Of the drugs examined, sodium salicylate , sodium benzoate and indomethacin caused a significant increase in the concentration of serum free tryptophan and stimulated the synthesis of 5-HT in the brain.”
“The injection of salicylate increased both the total and the free concentration of tryptophan in the liver.”
“The injection of salicylate causes a progressive increase in the holo-/apo-enzyme ratio and an increased content of tryptophan in the liver over a period of 3h.”
“Indomethacin (5 mM), phenylbutazone (5 mM), and salicylate (15 mM) prevent the active transport of the amino acid, L-tryptophan , across the small intestine of the rat.”
“ Salicylate (15 mM) significantly inhibits the active transport of L-tryptophan across the hamster small intestine; aspirin (15 mM) has no inhibitory effect.”
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