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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Salicylic Acid
supplement:
Sodium Bicarbonate
Research Papers that Mention the Interaction
“Pre‐administration with SA increased both platelet CD62P expression and TXB2/6‐keto‐PGF1&agr; ratio in female T2DM mice, while pretreatment with NaHCO3 caused the opposite effect.”
Salicylic acid retention impairs aspirin reactivity in type 2 diabetes“ Sodium bicarbonate given by mouth lowers the plasma salicylate level by increasing excretion and so relieves the hyperpnosa.”
“The administration of sodium bicarbonate to patients receiving sodium salicylate results in an increased excretion of free salicylate, with the renal clearances of free salicylate increasing rapidly above pH 7 in the urine.”
“Upon simultaneous treatment with sodium salicylate, NaHCO3 significantly reduced, and NH4Cl enhanced the incidence of the above histologic and teratologic effects, without significantly altering acid-base values.”
Chemically induced alterations in maternal homeostasis and histology of conceptus: their etiologic significance in rat fetal anomalies.“As has been shown by others, sodium bicarbonate promoted renal excretion of salicylate.”
SALICYLATE INTOXICATION IN CHILDREN--EXPERIENCE WITH PERITONEAL DIALYSIS AND ALKALINIZATION OF THE URINE.
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