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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Salicylic Acid
supplement:
Long Chain Fatty Acid
Research Papers that Mention the Interaction
“We conclude that salicylic acid decreases the mitochondrial activation and thus beta-oxidation of long chain fatty acids , presumably by sequestering extramitochondrial coenzyme A and possibly carnitine.”
Inhibition by salicylic acid of the activation and thus oxidation of long chain fatty acids. Possible role in the development of Reye's syndrome.“In the same preparation, salicylate had no effect … the oxidation of palmitoylcarnitine or palmitoyl-CoA. Salicylate appears to augment the initial step of palmitic acid oxidation by lowering the apparent Michaelis constant (Km) of long chain fatty acid : CoASH ligase (AMP) (EC 6.2.1.3) for palmitic acid.”
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