Possible Interaction: Salicylic Acid and Iron, Dietary

“The latter effect of salicylate is particularly expressed at increased Fe content.”

“It is assumed that salicylate increases intestinal Fe resorption and fetal transfer of Fe.”

“When given together, however, Fe and salicylate caused a drastic increase of LPO in liver, which was reduced by the simultaneous injection of ZnCl2.”

“Mn and Fe significantly increased total salicylate concentration in both embryos and maternal plasma at 6 h after salicylate treatment, with Mn having the greater effect.”

“Mn significantly enhanced the teratogenic effects of salicylate, Fe potentiated the salicylate effect but to a lesser extent than Mn, and Cu had little or no effect on salicylate teratogenicity.”

“Synthesis of salicylate in SM3 was derepressed even in the presence of iron , as was synthesis of the siderophores exochelin, mycobactin, and carboxymycobactin.”

“The biosynthesis of salicylic acid was under iron control; it was fully inhibited by 5 microM added iron in the growth medium.”

“Because some salicylate derivatives are known to chelate iron and because iron is thought to play a role in inflammatory tissue injury, we assessed the possibility that 5-ASA may behave as an iron chelator and thus may protect deoxyribose from iron-catalyzed .”

“The influence of salicylate on the status of iron (precipitated, colloidal or soluble) depends principally upon the pH and the prevailing concentrations of phosphate and Mg 2+ .”

“ Salicylic acid concentration increased about fourfold when iron was omitted from the medium, but this is not as great as the increase reported previously for this strain of M. smegmatis.”