Possible Interaction: Salicylic Acid and Calcium Supplement

“ Salicylate increases the red cell permeability for Ca2+ ( and Mg2+).”

“Our findings suggest that aspirin and salicylate induce Ca2+m remodeling, mitochondrial dysfunction, and cell death via ROS-dependent depolarization and VGCE activation.”

“The use of dinitrosalicylate will give erroneously high estimates of α-amylase activity, and it is clear that the effect of calcium on dinitrosalicylate reducing values has misled some workers into concluding that this ion affects α-amylase action patterns.”

“Finally we demonstrated that incubation with salicylate potentiated the increase in intracellular calcium during the depolarization.”

“Seven amino acids (glycine, l-isoleucine, l-phenylalanine, l-proline, l-serine, l-threonine, and l-tryptophan) and five organic acids (benzoic acid, citric acid, fumaric acid, SA , and succinic acid) increased in ' Ca.”

“An exogenous calcium supplement , provided under the conditions shown to attenuate the behavioral manifestation of salicylate-induced tinnitus, abolished the modification of the spontaneous activity induced by salicylate.”

“ Salicylic acid , an in vivo metabolite of aspirin, inhibits the uptake and enhances the release of calcium by mitochondria, thereby increasing the levels of cytoplasmic free calcium.”

“ SA concentrations higher than 100 micrograms/ml caused an immediate increase in urinary flow and in fractional excretion of sodium, potassium, chloride and calcium.”

“ Calcium and magnesium ions inhibited the effects of salicylate at pH 7.4 but not at pH 4.5.”

“A significant (p less than 0.01) decrease in plasma calcium level was also observed at 4 hr after oral administration of salicylic acid at a dose level of 177 mg/kg.”