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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Salicylic Acid
supplement:
Alpha-Ketoglutaric Acid
Research Papers that Mention the Interaction
“Kinetic analysis indicates that salicylic acid acts as a competitive inhibitor at the α-ketoglutarate binding site.”
Inhibition of Cardiac Mitochondrial Respiration by Salicylic Acid and Acetylsalicylate“It is shown that inhibition in succinate dehydrogenase and α-ketoglutarate dehydrogenase by salicylate contributes substantially to the cumulative inhibition of the Krebs cycle by salicylates.”
Kinetic Model of Mitochondrial Krebs Cycle: Unraveling the Mechanism of Salicylate Hepatotoxic Effects
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