Possible Interaction: Salicylic Acid and Adrenocorticotropic Hormone

“Since Cochran and others (1950) reported the development of Cushing's syndrome in a 12-year-old girl receiving …. aspirin daily for acute rheumatism, much work has focused on the possibility that the therapeutic and metabolic effects accompanying salicylate administration may be dependent … intermediary production of ACTH and/… corticoids.”

“A single injection of salicylate or salicylate plus ACTH was able to lower the hepatic cholesterol content within one hour after the treatment.”

“ACTH or salicylate plus ACTH also brought about 50 per cent reduction in serum cholesterol level from its initial control value within one hour.”

“The rise in the serum cholesterol level was about twofold in animals five hours after salicylate plus ACTH treatment.”

“ ACTH alone, which causes mobilization of free fatty acids had no appreciable effect on blood pressure responses to catecholamines, however, its administration followed by salicylate produced marked potentiation of the pressor responses to epinephrine and nor-epinephrine; the depressor response to isoproterenol was reduced.”

“ Sodium salicylate reduced the rate of release of both glycerol and fatty acids induced by DL-arterenol, glucagon, theophylline, ACTH , dexamethasone plus growth hormone, and high and low concentrations of dibutyryl cyclic AMP plus theophylline.”