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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“The mechanism may be that SAM can reverse the hypomethylation of c-myc and uPA genes , reduce their expression, and then inhibit tumor growth.”
“The protein and mRNA expressions of c-myc and uPA were remarkably reduced (all P < 0.01), and the hypomethylation of c-myc and uPA genes were reversed after SAM treatment.”
Inhibitory effect of S-adenosylmethionine on the growth of human gastric cancer cells in vivo and in vitro.“Immunohistochemical analysis of tumors showed the ability of SAM and MBD2-AS to significantly decrease tumoral uPA and MMP-2 expression along with levels of angiogenesis and survival pathway signaling molecules.”
“Treatment of MDA-231 cells with AdoMet , but not its unmethylated analogue S-adenosylhomocysteine, significantly inhibits uPA expression and tumor cell invasion in vitro and tumor growth and metastasis in vivo.”
“ SAM can reverse the methylation of c-myc and uPA in these two cell lines and reduce their expression.”
“The methylation of c-myc and uPA genes in two cell lines were reversed after SAM treatment.”
“Furthermore, treatment with demethylation inhibitor S-adenosylmethionine or stable expression of uPA short hairpin RNA significantly inhibits uPA expression and tumor cell invasion in vitro and tumor growth and incidence of lung metastasis in vivo.”
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