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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
S-Adenosylmethionine
drug:
Serotonin
Research Papers that Mention the Interaction
“ S-Adenosylmethionine , which has antidepressant properties, raises brain 5-hydroxytryptamine.”
Folic acid and psychopathology“Binding of serotonin to the catalytic site inhibits the access of SAM , thus preventing methylation of COMT substrates.”
“Using computational modeling, biochemical tests and cellular assays we show that serotonin actively competes with the methyl donor S-adenosyl-L-methionine (SAM) within the catalytic site.”
Serotonin-Induced Hypersensitivity via Inhibition of Catechol O-Methyltransferase Activity“One hour after SAM injection 5-HT biosynthesis was increased in the corpus striatum (55%), the hippocampus (3-fold) (82% 2 hr after SAM injection) and decreased in the olfactory bulbs (34%).”
“These area-related changes in 5-HT biosynthesis and metabolism might suggest a possible neurochemical substrate for the antidepressant properties of SAM.”
“The administration of S-adenosyl-L-methionine (SAMe) to rats caused an increase in 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxyindolacetic acid (5-HIAA) in some regions of the rat brain.”
“The 5-HT turnover rate, determined by the steady state kinetic method, was higher in rats receiving repeated administrations of SAMe.”
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