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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
S-Adenosylmethionine
supplement:
Phosphatidylethanolamine
Research Papers that Mention the Interaction
“ SAMe also contributes to the methylation of phosphatidylethanolamine to phosphatidylcholine.”
Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases.“Total methyl group incorporation into SL phosphatidylethanolamine using radiolabeled S-adenosyl-L-methionine as the donor was significantly depressed in the 3 week group at catalytic sites II and III.”
Adriamycin depresses in vivo and in vitro phosphatidylethanolamine N-methylation in rat heart sarcolemma“ SAMe ,without changing total phospholipid (PL) content,induced an increase in the phosphatidylcholine/phosphatidylethanolamine (PC/PE) molar ratio in both liver homogenateand microsomes and a significant enrichment of 16:0-20:4and 18:0-20:4 PC molecular species.”
“ Phosphatidylethanolamine N-methylation following incubation of membranes with S-adenosyl-L-methionine , a methyl donor for the enzymatic N-methylation, inhibited Nai+-dependent Ca2+ uptake by about 50%.”
“A specific decrease in the total available activity of AdoMet : phosphoethanolamine N-methyltransferase, as well as feedback inhibition of this enzyme by phosphocholine, and prevention of accumulation of phosphoethanolamine by down-regulation of ethanolamine synthesis may each contribute to effective control of phosphoethanolamine methylation.”
Synthesis of methylated ethanolamine moieties: regulation by choline in lemna.
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