Possible Interaction: S-Adenosylmethionine and Folate

“These findings suggest that dietary supplementation with SAM represents a useful therapeutic approach for age-related neurodegeneration which may augment pharmacological approaches to maintain acetylcholine levels, in particular during dietary or genetic compromise in folate usage.”

“Moreover, folate affects gene expression by regulating cellular S-adenosylmethionine ( SAM ) levels.”

“ Folate plays a major role in the formation of S-adenosylmethionine , the universal methyl donor, as well as in the formation of purine and thymidine synthesis for DNA and RNA.”

“shMTHFR tended to decrease intracellular S-adenosylmethionine (SAM) contents but folate depletion similarly decreased SAM in wildtype (WT), negative control (Neg), and shMTHFR cells, indicating that in cells of liver origin, shMTHFR does not exacerbate the methyl group supply in folate depletion.”

“Response was not moderated by BDNF, SNPs, or one–carbon cycle biomarkers, although increased folate concentrations were correlated with improved symptoms in the SAMe group ( r = − 0.57, p = 0.026).”

“Our first hypothesis is that as increased levels of folate lead to higher concentrations of SAM , SAM antagonizes the expression of CYP2E1, which results in decreased conversion of ethanol into acetaldehyde.”

“We demonstrate herein in SH-SY-5Y human neuroblastoma that both of these phenomena contribute to the increase in phospho-tau immunoreactivity following folate deprivation, and that supplementation with S-adenosyl methionine (SAM) prevents both the increase in kinase activity and the decrease in phosphatase activity.”

“The efficiency of folate metabolism has an impact on the availability of S-adenosylmethionine , a compound that is known to activate homocysteine flux through the transsulfuration pathway and is necessary for utilization of a downstream antioxidant called glutathione under the catalysis of glutathione S-transferase enzyme.”

“The efficiency of folate metabolism has an impact on the availability of S-adenosylmethionine (SAM), a compound that is known to activate homocysteine flux through the transsulfuration pathway.”

“Here we demonstrate that BACE (beta-secretase), as well as PS1, is regulated by methylation and that the reduction of folate and vitamin B12 in culture medium can cause a reduction of SAM levels with consequent increase in presenilin1 and BACE levels and with increase in A beta production.”