Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: S-Adenosylmethionine and Buthionine Sulfoximine

Research Papers that Mention the Interaction

Buthioninesulfoximine administration depressed the elevation of S-adenosylmethionine , but increased the catabolism of cysteine to taurine.
Biochimie  •  2013  |  View Paper
Antioxidants such as trolox or N-acetyl cysteine prevented this synergistic toxicity of SAMe plus AA or SAMe plus BSO , respectively.
In E47 cells, but not pyrazole hepatocytes, the combination of SAMe plus BSO lowered levels of the antioxidant transcription factor Nrf2.
American journal of physiology. Gastrointestinal and liver physiology  •  2006  |  View Paper
SAM induced an earlier onset of hepatocyte mitotic activity, and reduced the inhibitory effect of BSO.
Arzneimittel-Forschung  •  2000  |  View Paper
Rat brain SAM levels were markedly increased after methionine administration, whereas the convulsant, L‐methionine‐dl‐sulphoximine (MSO), produced a 35 per cent decrease in whole brain content of S‐adenosyl‐L‐methionine (SAM).
SAM levels were reduced by about 50 per cent in the cerebellum, striatum, cortex and hippocampus 3 and 6 h after MSO.
Journal of neurochemistry  •  1975  |  View Paper