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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“ Buthioninesulfoximine administration depressed the elevation of S-adenosylmethionine , but increased the catabolism of cysteine to taurine.”
Significance of alterations in the metabolomics of sulfur-containing amino acids during liver regeneration.“Antioxidants such as trolox or N-acetyl cysteine prevented this synergistic toxicity of SAMe plus AA or SAMe plus BSO , respectively.”
“In E47 cells, but not pyrazole hepatocytes, the combination of SAMe plus BSO lowered levels of the antioxidant transcription factor Nrf2.”
“ SAM induced an earlier onset of hepatocyte mitotic activity, and reduced the inhibitory effect of BSO.”
“Rat brain SAM levels were markedly increased after methionine administration, whereas the convulsant, L‐methionine‐dl‐sulphoximine (MSO), produced a 35 per cent decrease in whole brain content of S‐adenosyl‐L‐methionine (SAM).”
“ SAM levels were reduced by about 50 per cent in the cerebellum, striatum, cortex and hippocampus 3 and 6 h after MSO.”
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