“The dimethylated arsenic (DMA) levels in … livers of hamsters treated with SAM … arsenic trioxide were significantly high, that is, 2 times as high as the control value at 6 hours, and 1.5 times as high as the control value at 24 hours after the administration of arsenic trioxide.”
“The SAM level was 63.9 +/- 6.5 nmol/g following oral administration of 1.5 mg/kg of arsenic trioxide , which was 14% lower than the control level (t-test, p less than 0.05).”