Possible Interaction: Rutin and Vitamin C

“The cytoprotective effect of rutin , but not that of dihydroquercetin, was enhanced in the presence of ascorbic acid.”

“The combined effect of ascorbic acid and rutin suggests that this combination of compounds is potentially effective against skin damage caused by UV radiation.”

“In the context of the results obtained, the observed cytoprotective effect of the cooperation of rutin and ascorbic acid results not only from the overlapping properties of the compounds.”

“Nevertheless, rutin and ascorbic acid used separately or together have countered these changes to varying degrees.”

“The combination of ascorbic acid and rutin had higher antioxidant properties compared to the activity of the single compound alone, and showed a stronger effect against UV-induced reactive oxygen species generation.”

“Combined treatment with VC and rutin promoted the formation of PDLSC sheets and enhanced the osteogenic differentiation potential of the cell sheets.”

“The combination of ascorbic acid and rutin , often used in oral preparations, due to antioxidant and anti-inflammatory properties, can be used to protect skin cells against the effects of UV radiation from sunlight.”

“The combination of rutin and ascorbic acid also showed a stronger cytoprotective effect than when using either compound alone.”

“Therefore, the synergistic effect of rutin and ascorbic acid creates a potentially effective protective system against skin damages caused by UVA and UVB radiation.”

“The presence of ascorbic acid enhanced the protective effect of quercetin and rutin against oxidative stress in sickle Hb and lipid peroxidation.”

“It is suggested that ascorbic acid and rutin interacts with tocopherol at the surface of or the interface with the membrane, and that rutin simultaneously interacts with ascorbic acid.”

“When these compounds are used in combination, an additive effect is observed with alpha-tocopherol and ascorbic acid or rutin, while a supra-additive effect (synergism) is noted with ascorbic acid and rutin.”

“The combination of rutin with ascorbic acid apparently assists these diseased areas to recover, for the observations in this limited series of cases eliminated the omnipresent induration, swelling and painful areas with discoloration without fail in a remarkably short period of time.”

“ Rutin increased …), ascorbic acid content (AA) and total reactive antioxidant potential (TRAP) in the brain; glutathione S-transferase (GST) activity and TRAP in the gills; SOD, CAT …; CAT and GST activity and TRAP levels in the kidneys; and glutathione peroxidase activity, NPSH, AA levels and TRAP in the muscle.”