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“Urea (alone and in association with isopropanol and propylene glycol) and isopropanol (alone and in association with propylene glycol ) influenced significant and negatively rutin liberation in diverse parameters: flux (microg/cm(2).h); apparent permeability coefficient (cm/h); rutin amount released (microg/cm(2)); and liberation enhancement factor.”
Drug development and industrial pharmacy • 2009 | View Paper
“ Propylene glycol , which was used as the rutin solvent, inhibits the spreading power of hyaluronidase and this inhibition is increased by a highly significant factor when rutin is also present.”