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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Rolipram
supplement:
Oligomeric Procyanidin Complex
Research Papers that Mention the Interaction
“At 0.1 microM OPC rolipram increased peak force by 82.8 +/- 8.9% (n = 6, P < 0.001), reduced TPT by 73 +/- 6% (n = 6, P < 0.005) and increased THR by 27 +/- 5% (P < 0.01).”
“The combination of OPC 3911 and rolipram intensified the Isi to 101 +/- 5% (n = 3).”
“The results suggest that rolipram exerts its potentiating effect on OPC 3911 via an increased Isi.”
The inotropic mechanism of the phosphodiesterase inhibitor OPC 3911 alone and in combination with rolipram, studied in papillary muscles of ferret and guinea-pig and isolated myocytes of guinea-pig ventricular muscle.“When OPC 3911 or milrinone was combined with rolipram more than additive effects on aortic relaxation and cAMP content were obtained.”
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