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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Rolipram and Arachidonate



Research Papers that Mention the Interaction

The selective phosphodiesterase IV inhibitors, rolipram and Ro 20-1724, and the non-selective phosphodiesterase inhibitor, theophylline, elicited a concentration-dependent inhibition of arachidonate release (EC50 = 1.3 x 10(-6) M, 3.2 x 10(-6) M and 3.7 x 10(-4) M respectively).
European journal of pharmacology  •  1995  |  View Paper
Oral pretreatment, prior to antigen challenge in sensitized guinea-pigs, with rolipram or Ro 20-1724 (PDE4 inhibitors) but not milrinone (PDE3 inhibitor) significantly reduced the arachidonate release from alveolar macrophages.
The European respiratory journal  •  1998  |  View Paper