Possible Interaction: Riboflavin and Iron, Dietary

“ Riboflavin given in addition to iron resulted in a significant increase in circulating plasma iron and in iron stores, relative to the placebo.”

“Objectives Riboflavin (vitamin B2) has been shown in animal studies to affect the absorption and metabolism of iron.”

“Studies have indicated a role for riboflavin in the absorption and use of iron.”

“Of the 19 micronutrients investigated, the mean daily intake of eight (calcium, iron , zinc, vitamin A, riboflavin , nicotinic acid, pantothenic acid and biotin) fell below the recommended dietary allowance (RDA) at both interceptions.”

“ Riboflavin enhances the haematological response to iron , and its deficiency may account for a significant proportion of anaemia in many populations.”

“Riboflavin has the capacity to form complexes, and supplementation of riboflavin may result in increased absorption of zinc and iron , thus increasing the cellular transport.”

“ Dihydroriboflavin rapidly reduces the higher oxidation states of iron and the hydroxy radicals which are the products of the hemeprotein/hydrogen peroxide reaction.”

“GO terms analysis suggests that iron and riboflavin coordinately regulate specific physiological functions involving redox metabolism.”

“Recently the close metabolic feedback between iron and riboflavin , another pivotal biological redox agent, began to draw attention in bacteria.”

“Thus, iron and riboflavin highly affect the transcriptomics responses induced by each other in S. flexneri.”

“ Riboflavin had a stronger enhancement on SMX degradation and iron reduction than AQDS, but the enhancement was not positively correlated with electron shuttles concentration.”

“In bacteria, iron availability influences expression of riboflavin biosynthetic genes.”

“Notably, the metabolism of iron and riboflavin seem to be intrinsically related across life kingdoms.”