Possible Interaction: Riboflavin and Folate

“However, endogenous photosensitizers, like riboflavin and uroporphyrin, absorbing UVA and visible light, can cause photosensitization of folates.”

“It has been proposed that riboflavin may act together with folate to lower plasma tHcy, particularly in individuals with the thermolabile MTHFR T variant.”

“This association may be explained by increased intakes of folate and riboflavin.”

“A novel interaction between this folate polymorphism and riboflavin (a co-factor for MTHFR) has recently been identified.”

“ Riboflavin may interact with folate to modulate the effect.”

“ Riboflavin supplement enhanced the response to low-dose folate in people carrying at least one T allele and having polyps.”

“ Folate seemed to be a risk factor, especially when vitamin B2 intake was low; vitamin B2 was inversely associated with adenomas, especially with relatively high folate intake.”

“Significant differences were observed between genotypes only when the supply of both folate and riboflavin was limited in the medium, which resulted in increased homocysteine accumulation and decreased methionine production in the T/T genotype.”

“ Folate is shown to … state of riboflavin in a diffusion controlled reaction and with triplet‐excited state of riboflavin in a somewhat slower reaction with 3kq = 4.8 × … s−1 in aqueous phosphate buffer at pH 7.4, ionic strength of 0.2 mol L−1, and 25°C.”