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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Riboflavin
Research Papers that Mention the Interaction
“The present investigation determined that ADR administration inhibited flavin adenine dinucleotide (FAD) biosynthesis from riboflavin in rat skeletal muscle in a dose-related manner compared to results in pair-fed controls.”
Inhibition of flavin metabolism by adriamycin in skeletal muscle.“ Adriamycin has been shown to form a 1:1 stoichiometric complex with riboflavin , as well as to compete for binding to tissue proteins.”
“These findings in an animal model raise the possibility that defects of riboflavin nutriture, either dietary or drug‐induced, may be a determinant of Adriamycin toxicity.”
“The presence of urocanic acid in the skin suggests that significant degradation of ADR could occur in the presence of biologically relevant concentrations of riboflavin if patients treated with ADR are exposed to sunlight.”
The enhancement of riboflavin-mediated photo-oxidation of doxorubicin by histidine and urocanic acid“ Adriamycin produced saturable, concentration-dependent upfield shifts of the proton signals of both FMN and FAD.”
“These results suggest complex formation between Adriamycin and FMN or FAD via π-π ring stacking interactions occurring between the anthracycline ring of Adriamycin and the isoalloxazine ring of the flavins.”
“Abstract The addition of Adriamycin to a solution containing flavin mononucleotide (FMN) resulted in an upfield shift in the signals of the aromatic ring protons H(6,9) and the 8α, 7α methyl protons of FMN.”
“These results suggest that FMN and Adriamycin form a complex via ring-ring stacking.”
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