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Last Updated: 3 years ago

Possible Interaction: Riboflavin and Cupric Cation

supplement:

Riboflavin

supplement:

Cupric Cation

Research Papers that Mention the Interaction

Photoactivated riboflavin in the presence of Cu(II) generates reactive oxygen species (ROS) which can hemolyze human red blood cells (RBC).
Biochemistry (Moscow)  •  2005  |  View Paper
Riboflavin in a 2:1 stoichiometry with Cu(II) leads to maximum K(+) loss and up to 45% hemolysis.
Biochimica et biophysica acta  •  2000  |  View Paper
The FMN hydrolysis was strongly inhibited by Cu2+ and pCMB, but activated by guanosine.
Biochemistry and molecular biology international  •  1997  |  View Paper
Riboflavin is known to generate superoxide anion upon photoillumination and in the presence of Cu(II) causes fragmentation of DNA.
Using fluorescence quenching experiments, it is shown that riboflavin binds to protein and causes fragmentation which in the presence of Cu(II) is enhanced.
Biochemistry and molecular biology international  •  1994  |  View Paper
Riboflavin , in the presence of Cu(II) , caused breakage of calf thymus DNA and supercoiled pBR322 plasmid DNA.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  1993  |  View Paper
The cell membrane permeability of this engineered strain was increased and its riboflavin production (1.45–3.56 μM) was positively correlated to Cu2+ (0–0.5 mM).
Biotechnology and bioengineering  •  2020  |  View Paper
RF caused fragmentation of trypsin and the effect was further enhanced, when Cu(II) was added to the reaction.
Indian journal of biochemistry & biophysics  •  2006  |  View Paper