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Last Updated: 2 years ago

Possible Interaction: Riboflavin and Ascorbate

supplement:

Riboflavin

supplement:

Ascorbate

Research Papers that Mention the Interaction

It is proposed that photoexcited riboflavin can perform a one-electron oxidation of ascorbate generating a riboflavin radical.
Riboflavin in the presence of light stimulates the formation of ESR-detectable ascorbyl semiquinone radicals and stimulates O2 consumption (oxidation) by ascorbate in a manner dependent upon the concentration of riboflavin.
This 'pro-oxidant' activation of ascorbate by riboflavin is discussed in the context of previous studies on riboflavin phototoxicology.
Experimental eye research  •  1987  |  View Paper
In contrast, ascorbate blocked the effects of rose bengal but only partially blocked the effects of riboflavin.
Experimental eye research  •  1981  |  View Paper
FMN antagonists and Fe*-complexing agents (5, 9), serotonin, reduced glutathione, ascorbate , diethylstilbestrol, cytochrome c, and anaerobiosis (7) inhibited the activity of the FMN + Fe* or of the FMN-supplemented preparations.
The Journal of biological chemistry  •  1963  |  View Paper