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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“It is unclear, however, whether silymarin might interfere with the effect of interferon or ribavirin.”
Milk thistle and the treatment of hepatitis.“Compared with the animals in ribavirin group, silymarin significantly decreased the area under the plasma concentration‐time curve (AUC0–t) and the peak plasma concentration (Cmax) of ribavirin and ribavirin base by 31.2–44.5% and 48.9–50.0%, respectively.”
“This study indicates that the therapeutic efficacy of ribavirin may be compromised by the concurrent administration of herbal medicines/dietary supplements containing silymarin , glycyrrhizin, or oxymatrine.”
Effects of Silymarin, Glycyrrhizin, and Oxymatrine on the Pharmacokinetics of Ribavirin and Its Major Metabolite in Rats“Pre-treatment with silymarin reduced the toxicity of ribavirin.”
“Morphometric analysis indicated significant reduction in the area of necrosis and fibrosis on ribavirin treatment and this was further reduced after the addition of silymarin.”
“When silymarin was combined with ribavirin , the serum activities of AST and ALP were further decreased, indicating a beneficial additive effect.”
Effect of Ribavirin Alone or Combined with Silymarin on Carbon Tetrachloride Induced Hepatic Damage in Rats
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