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Last Updated: 2 years ago

Possible Interaction: Ribavirin and Silymarin

supplement:

Silymarin

Research Papers that Mention the Interaction

It is unclear, however, whether silymarin might interfere with the effect of interferon or ribavirin.
Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates  •  2001  |  View Paper
Compared with the animals in ribavirin group, silymarin significantly decreased the area under the plasma concentration‐time curve (AUC0–t) and the peak plasma concentration (Cmax) of ribavirin and ribavirin base by 31.2–44.5% and 48.9–50.0%, respectively.
This study indicates that the therapeutic efficacy of ribavirin may be compromised by the concurrent administration of herbal medicines/dietary supplements containing silymarin , glycyrrhizin, or oxymatrine.
Phytotherapy research : PTR  •  2016  |  View Paper
Pre-treatment with silymarin reduced the toxicity of ribavirin.
Mutation research  •  2013  |  View Paper
Morphometric analysis indicated significant reduction in the area of necrosis and fibrosis on ribavirin treatment and this was further reduced after the addition of silymarin.
When silymarin was combined with ribavirin , the serum activities of AST and ALP were further decreased, indicating a beneficial additive effect.
Drug target insights  •  2007  |  View Paper