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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Retinyl Palmitate and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

Both … DOX significantly (p<0.05) increased with the index and frequency of damages, clastogenic and/or aneugenic effects with the augmenting of micronuclei, demonstrating … cytotoxicity interference on the ratio of normochromatic to polychromatic erythrocytes and bone marrow cells of mice, that were found to reduce in RP treatment ….
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie  •  2017  |  View Paper
Pretreatment of rats with two daily subcutaneous injections of retinol palmitate (0.25 g/kg body wt), for 2 days, before injecting doxorubicin , inhibited peroxidation of heart and brain membrane lipids.
Archives of biochemistry and biophysics  •  1993  |  View Paper
However RP failed to potentiate the antitumor effects of adriamycin (ADM) and 6-mercaptopurine (6-MP) against sarcoma 180.
…,RP (167 mg/kg, or 333 mg/kg) enhanced the antitumor effects … 50 mg/kg), MTX (1 mg/kg, or 2 mg/kg), ADM (0.2 mg/kg), ACNU (5 mg/kg) and cis-dichlorodiammine-platinum (CDDP) (… extent, but it did not potentiate the antitumor effect of 5-FU.
Japanese journal of cancer research : Gann  •  1985  |  View Paper