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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Retinaldehyde
supplement:
Vitamin E
Research Papers that Mention the Interaction
“ All-trans retinoate, d-α-tocopheryl acid succinate , and dihomogeranoate are not activated themselves, but at low concentrations extensively inhibit activation ofcis-acids (oleate,cis-vaccenate, petroselenate, linoleate, linolenate, arachidonate) and thetrans-diunsaturated linelaidate but do not affect activation of palmitate ortrans-monounsaturated acids elaidate andtrans-vaccenate.”
Activation of long chain fatty acids by subcellular fractions of rat liver: I. Activation oftrans-unsaturated acids“In light of the known antioxidant mechanism of retinoids, the data suggest that by limiting autooxidation of all-trans retinol, alpha-tocopherol strongly promotes its antioxidant effectiveness.”
“On the other hand, when alpha-tocopherol and all-trans retinol were combined, the consumption of both antioxidants was significantly delayed, indicating reciprocal protection.”
“Synergistic antioxidant interactions between all-trans retinol and alpha-tocopherol were also evident when peroxidation was evaluated as production of malondialdehyde.”
“While all-trans retinol alone was poorly effective, the combination of all-trans retinol with alpha-tocopherol caused an inhibition period far beyond the sum of the inhibition periods observed with individual antioxidants, providing evidence of synergistic interactions.”
Synergistic interactions between vitamin A and vitamin E against lipid peroxidation in phosphatidylcholine liposomes.
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