Possible Interaction: Resveratrol and Uridine Triacetate

“RESULTS RS si gnificantly inhibited tau ag gregation and tau oligomer-induced cytotoxicity, and blocked the uptake of extracellular tau oligomers by N2a cells.”

“We found that activation of Sirt1 by resveratrol enhanced tau exon 10 inclusion, leading to 4R-tau expression.”

“Our results showed that resveratrol significantly inhibited Na3VO4-induced hyperphosphorylation of tau at the Ser396 (p-S396-tau) site, which is upregulated in the hippocampus of Alzheimer's disease (AD) brains and principally linked to AD-associated cognitive dysfunction.”

“Here we show that resveratrol , a polyphenol, significantly induces PP2A activity and reduces Tau phosphorylation at PP2A-dependent epitopes.”

“More importantly, pretreatment of neurons with Resveratrol or Quercetin significantly reduced the levels of caspase-3 cleaved- and hyperphosphorylated tau associated with HSV-1 infection.”

“Interestingly, pretreatment with resveratrol almost restored the expression of SIRT1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests.”

“When cells were pretreated with resveratrol cell viability increased along with a significant decrease in activated caspases, cleaved Tau , and NFT formation.”

“Our data demonstrated that resveratrol induces cognitive enhancement and neuroprotection against amyloid and tau pathologies.”

“In both groups, RES decreased the phosphorylation rate of Tau at Ser199 and Ser296.”

“In conclusion, in addition to its antioxidant potential, RES inhibits Tau phosphorylation in rat’s brain by activating PP2A protein and AMPK/PI3K/Akt-induced inhibition of GSK3β.”

“ Resveratrol reduced the level of total hyperphosphorylated tau in IHC sections (p=0.036), and morin exhibited a tendency to do so (p=0.29), while the two drugs tended to increase the proportion of solubilizable tau that was hyperphosphorylated, as detected in blots.”