Possible Interaction: Resveratrol and Temozolomide

“ Resveratrol increased the efficacy of TMZ by restraining cell proliferation, tumor growth, and promoting cell apoptosis in glioma cells.”

“ Resveratrol , a natural compound, was shown to potentiate anticancer effect of TMZ in GBM cells through the abrogation G2-arrest and mitotic catastrophe resulting in senescence of GBM cells.”

“The synergistic antitumor effect against glioma cells was observed in the combinational treatment of Res and Tem.”

“Treatment of malignant cells with 50 μM RESV and temozolomide ( TMZ ) for 72 h significantly enhanced cytotoxicity compared with treatment with TMZ alone (P < 0.0001).”

“Isobolographic analysis indicated that the combination of TMZ and resveratrol has a synergistic effect.”

“Moreover, an in vivo mouse xenograft study also showed that coadministration of resveratrol and TMZ reduced tumor volumes by suppressing ROS/ERK-mediated autophagy and subsequently inducing apoptosis.”

“ TMZ induced both apoptotic cell death and cytoprotective autophagy through a reactive … and extracellular signal-regulated kinase (ERK) activation, which was suppressed by resveratrol , resulting in a decrease in autophagy and an increase in apoptosis, suggesting that … plays a crucial role in the fate of cells after TMZ treatment.”

“Taken together, our data indicate that TMZ-induced ROS/ERK-mediated autophagy protected glioma cells from apoptosis, and the combination of resveratrol with TMZ could improve the efficacy of chemotherapy for brain tumors.”

“This study investigated the mechanism behind TMZ-induced cell death and the possibility that resveratrol might increase TMZ efficacy.”

“In this contest, resveratrol reduces cell invasion and increases the efficacy of radiotherapy (radiosensitizer effects) and temozolamide.”

“The data showed that combination treatment with TMZ and resveratrol resulted in an enhanced antitumor potential of TMZ, decreased the 50% inhibiting concentration (IC50) of TMZ and increased the induction of apoptosis in TMZ-resistant T98G cells.”

“As a proof of principle, we show that these formulations containing resveratrol markedly decrease astrocytoma viability, particularly in combination with temozolomide , a first line chemotherapeutic for astrocytoma.”

“Although resveratrol combined with TMZ (Res/TMZ) has been reported to be used to treat GBMs, it remains unclear whether this combination is broad-spectrum for all glioma cells until now, especially for GBM cells/cases with dual drug resistance.”

“ Resveratrol had regulatory effect on the expression of MGMT and it could significantly down-regulate MGMT overexpression caused by TMZ.”

“Previous studies have shown that a variety of drugs such as interferon-β (IFN-β), levetiracetam (LEV), resveratrol , and valproic acid (VAP) increased the sensitivity of TMZ through MGMT-dependent or MGMT-independent mechanisms.”