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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Resveratrol
drug:
Sorafenib
Research Papers that Mention the Interaction
“In addition, resveratrol enhanced sorafenib induced cell growth inhibition in aerobic glycolytic HCC cells.”
By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice“Beside, RES potentiated sorafenib induced inhibitory effect on constitutive STAT3 and STAT5 phosphorylation, apoptotic effects in 786-O cells, and this correlated with down-regulation of various oncogenic gene products.”
“Combination of RSV and SF showed higher cytotoxicity on MCF7 cells than their individual treatment.”
“Present study is aimed to preliminarily … our hypothesis that the combination of resveratrol (RSV), a natural antioxidant, and lower dose of sorafenib (SF), a multi-kinase inhibitor and a component of ERK1/2 (extracellular signal-regulated kinase 1/2) pathway, would augment apoptosis in human breast cancer MCF7 cells.”
“The combination of RSV and lower dose of SF at 6μM showed enhanced apoptotic activity than SF alone.”
“The increase in apoptosis and signaling protein expressions with RSV and SF combinational treatment were increased over time.”
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