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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Resveratrol
drug:
Palmitate
Research Papers that Mention the Interaction
“Oil Red O staining revealed that resveratrol could significantly ameliorate the excessive triglyceride accumulation in HepG2 cells induced by palmitate.”
Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway.“Principal Findings We show that, unexpectedly, RSV promotes an amplification of palmitate toxicity and cell death and that this mechanism is likely due to a perturbation of palmitate accumulation in the triglyceride form and to a less important membrane fluidity variation.”
“ Resveratrol suppressed lysine acetylation and S36 phosphorylation of p66Shc, ROS production, and NF-κB activation induced by HG and PA , while sirtinol boosted these processes.”
SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc“Importantly, pre‐treatment of the cells with resveratrol completely abrogated the phosphorylation of ERK1/2, JNK, and IKKα/IKKβ in palmitate treated cells.”
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