Possible Interaction: Resveratrol and Paclitaxel

“ Paclitaxel induced the levels of both DNA damages in the sperms, but resveratrol ameliorated this effect.”

“It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel.”

“These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers.”

“Nine phenolic antioxidants ((+)-catechin, (-)-epicatechin, fisetin, gallic acid, morin, myricetin, naringenin, quercetin and resveratrol ) were tested for inhibition of paclitaxel metabolism.”

“Here, the possibility that resveratrol (Res), an anticancer plant polyphenol, could increase the susceptibility of breast cancer cells to paclitaxel (Pacl) by affecting E2/ERα/NGB pathway has been evaluated.”

“ RES , dose-dependently, suppresses the expression of survivin, a molecular biomarker of cancer and a member of the inhibitor of apoptosis (IAP) family and its co-administration with PTX inhibits the effect of this drug on cell viability.”

“These data show that RES increases the sensitivity of PTX resistant renal cells to drug treatment.”

“This dramatically counteracts the effects of RES on cell survival in the presence of PTX.”

“Importantly, RES augmented the effects of paclitaxel in both cell lines.”

“Taken together, our results indicate that resveratrol may have the potential to negate the therapeutic efficacy of taxol and suggest that consumption of resveratrol-related products may be contraindicated during cancer therapy with taxol.”

“This pronounced antagonistic function of resveratrol against taxol was associated with changes in multiple signal transduction pathways, but not with tubulin polymerization.”

“Unexpectedly, resveratrol effectively prevented tumor cell death induced by taxol in 5637 bladder cancer cells.”

“After being treated with resveratrol at different concentrations separately, the expressions of HIF-1alpha, mdr1 and MRP1 in CNE2 cells decreased significantly as compared with paclitaxel alone or paclitaxel plus verapamil (P<0.01).”

“Combined with paclitaxel , 25, 50, 100 and 200 micromol/L of resveratrol increased the apoptotic rate of CNE2 cells from (22.14+/-1.09)% to (23.24+/-1.37)%, (27.57+/-2.01)%, and (30.36+/-2.31)%, respectively.”

“Although simultaneous exposure to resveratrol plus paclitaxel did not result in significant synergy, resveratrol (10 microM, 3 days) significantly enhanced the subsequent antiproliferative effect of paclitaxel.”

“ Resveratrol (10 microM, 3 days) similarly enhanced the subsequent apoptotic effects of paclitaxel.”

“These results suggest that resveratrol may be a promising alternative therapy for lung cancer and that lung cancer cells exposed to resveratrol have a lowered threshold for killing by paclitaxel.”

“Administration of RES combined with PAC prevented, while PAC induced, neutropenia and lymphocytosis, and increased the percentage of ANAE-positive lymphocytes.”