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Last Updated: 3 years ago
supplement:
Resveratrol
Research Papers that Mention the Interaction
“The potentiating effect of RVT was significantly inhibited by L-NG-nitroarginine methyl ester (L-NAME, 10−4 M, for 30 min) incubation in both groups.”
Resveratrol reverses diabetes-related decrement in sildenafil-induced relaxation of corpus cavernosum in aged rats“Using the model of endothelial dysfunction in rats induced by L-NAME it was shown, that RES markedly attenuated the inhibition effect of L-NAME on NO synthesis.”
“Treatment of the arterial rings with the eNOS inhibitor L-NAME , but not with indomethecin or endothelium denudation, obviously affected the relaxant effects of resveratrol.”
“The … of resveratrol on 125I-MCP-1 binding to THP-1 cells and on … expression determined by FACS analysis was attenuated by treatment with L-NAME (NOS inhibitor), PD98059 (MAPK inhibitor) and LY294002 (PI3K inhibitor), whereas neither X/… oxygen species generator) nor ICI182780 (estrogen receptor antagonist) had any effect.”
“In the presence of the endothelium, … soluble guanylate cyclase inhibitor), Nω-nitro-l-arginine methyl ester (L-NAME, nitric oxide synthase inhibitor), tetraethylammonium (TEA, nonselective calcium activator potassium channel blocker), 4-aminopyridine (… propranolol (β-adrenergic receptor blocker) led to a significant reduction in the vasorelaxation effect induced by resveratrol.”
“All the effects of Res demonstrated were inhibited by L-NAME (a nitric oxide (NO) synthase inhibitor) and MB [a cyclic guanosine monophosphate (cGMP) inhibitor].”
“… N-nitro-L-arginine methyl ester (L-NAME, 10−4 M) or soluble guanylate cyclase inhibitor 1H-[1,2,4]…-1-one (ODQ, 10−5 M) caused a significant inhibition on relaxation response to RVT , whereas cyclooxygenase inhibitor indomethacin (10−5 M) … responses of corpus cavernosum strips to RVT.”
“Treatment with L-NAME (a nitric oxide synthase inhibitor), glibenclamide and tetraethylammonium (TEA) significantly attenuated the vasorelaxing effect of Res.”
“And the effect of Res was blocked completely by either L-NAME (an eNOS inhibitor) or MB (a cGMP inhibitor), and partly by either DS (a PKC inhibitor) or Glybenclamide (a KATP inhibitor).”
“Cotreatment with l-NAME significantly attenuated the antirestenotic properties of Resv.”
Essential role of ER-alpha-dependent NO production in resveratrol-mediated inhibition of restenosis.
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