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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Resveratrol
drug:
Gentamicin
Research Papers that Mention the Interaction
“Co-administration … concentrations of resveratrol increased the activity … aminoglycosides, including gentamicin , kanamycin, neomycin, streptomycin and tobramycin, up to 32-fold against S. aureus, while the effect was lower (2-4-… reduction in minimum inhibitory concentration) for other Gram-positive pathogens (i.e. Staphylococcus epidermidis, Enterococcus faecium and Enterococcus faecalis).”
Resveratrol enhances the efficacy of aminoglycosides against Staphylococcus aureus.“Histopathological examination showed that resveratrol prevented partly gentamicin induced tubular damage.”
“In this study, we aimed to investigate the possible protective effect of resveratrol on gentamicin induced nephrotoxicity.”
Gentamicin-induced nephrotoxicity in rats ameliorated and healing effects of resveratrol.“This study demonstrates that the contractile effect of gentamicin on mesangial cells can be prevented by incubation with resveratrol at an optimal dose of 10 microM, as it blunted the gentamicin-induced reduction in planar cell surface area and the number of contracted cells.”
“These results indicate that the QSI resveratrol can significantly enhance the effects of aminoglycoside antibiotics (e.g. tobramycin, gentamicin , amikacin and netilmicin) on P. aeruginosa PAO1 biofilms.”
Can the quorum sensing inhibitor resveratrol function as an aminoglycoside antibiotic accelerant against Pseudomonas aeruginosa?
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