“ Chemopreventive agents may act by blocking carcinogen activation, inducing carcinogen metabolism (such as the action of oltipraz on aflatoxin), altering intracellular … cyclooxygenase-2 [COX-2]).9 Numerous compounds in animal models exhibit chemopreventive effects, including phytochemicals (i.e., curcumin, resveratrol , epigallocatechin gallate, caffeine, silymarin, silibinin, … virus; SAMe, S-adenosylmethionine.”