Possible Interaction: Resveratrol and Calcium Supplement

“In addition, live cell microscopy demonstrates that RES causes an early biphasic increase in the concentration of free intracellular calcium ([Ca2+]i), probably resulting from depletion of the endoplasmic reticulum stores in breast cancer cells.”

“ RSV treatment improved intracellular Ca 2 + responses, mitochondrial function, suppressed the generation of cytokine (IL-1β and TNF-α), cytosolic and mitochondrial ROS in the SH-SY5Y cells.”

“Conclusions The results suggest that resveratrol inhibits thrombin-induced platelet aggregation through decreasing Ca 2 + release from its stores and inhibiting store-operated Ca 2+ influx into platelets.”

“In the present study, it was confirmed that resveratrol inhibited the HPV E6 mRNA, HPV E6 protein and phosphorylated retinoblastoma protein (p-pRb1) levels, and increased the p53 protein levels in HeLa and Ca Ski cells, as well as in subcutaneous tumor tissue grown from HeLa cells.”

“Furthermore, RSV treatment also decreases ER calcium storage and store operated calcium entry (SOCE), which induces endoplasmic reticulum (ER) stress, thereby, activating AMPK and inhibiting the AKT/mTOR pathway.”

“In addition, RESV can prevent the increase in vasoconstrictors, such as angiotensin II (AII) and endothelin-1 (ET-1), as well as intracellular calcium , in mesangial cells.”

“Finally we showed that resveratrol is able to down‐regulate InsP3 and ATP effects on intracellular calcium [Ca2+]i fluxes as well as the effects of ATP and IONO on oxidative stress in CML cells.”

“In permeabilized HepG2 cells, we further demonstrated that the effect of the resveratrol was indeed synergistic with that of Ca2+ and Ca2+ is necessary for resveratrol-induced MPT opening.”

“Pretreatment with resveratrol reduced ATP-induced SR Ca release and SR Ca content.”

“ Resveratrol (25 μmol L-1 ) elevates [ Ca2+ ]c and potentiates glucose-stimulated insulin secretion.”