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Last Updated: 3 years ago

Possible Interaction: Resiniferatoxin and Calcium Supplement

Research Papers that Mention the Interaction

In human dorsal root ganglion cultures, RTX induced a prolonged increase in intracellular calcium in vanilloid-sensitive neurons, while leaving other, adjacent neurons unaffected.
The Journal of clinical investigation  •  2004  |  View Paper
RTX significantly upregulated phagocytosis (p < 0.05), markedly … release of IL-1β (p < 0.01), ifCa2+ , hydrogen peroxide (H2O2), and slightly downregulated the Nitric Oxide Synthase (NOS) activity, NOS activity-to-arginase activity … levels of Lactate Dehydrogenase (LDH)-based cytotoxicity, and the production of IL-6 and IFN-γ.
Endocrine, metabolic & immune disorders drug targets  •  2019  |  View Paper
The data demonstrate that VR1 receptor agonists capsaicin and resiniferatoxin lead to a sustained increase in intracellular calcium and sodium in a concentration-dependent manner, followed by cell death.
The Journal of pharmacology and experimental therapeutics  •  2002  |  View Paper
Capsaicin analogs capsazepine and resiniferatoxin also produce inhibition of CCE via block of I(CRAC).
The Journal of pharmacology and experimental therapeutics  •  2001  |  View Paper
Several members of the RTX family of toxins, including ACT, have been shown to induce intracellular calcium increases, through different mechanisms.
The Journal of Biological Chemistry  •  2009  |  View Paper
Resiniferatoxin also caused … a Ca2+‐ and lipid‐dependent kinase (or kinases) in the cytosolic fraction of dorsal root ganglia, at concentrations (100 nM to 10 µM) higher … displacement of [3H]resiniferatoxin binding or translocation of protein kinase C. Capsaicin (up to 10 µM) was unable to mimic this effect.
Journal of neurochemistry  •  1995  |  View Paper