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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Resiniferatoxin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In human dorsal root ganglion cultures, RTX induced a prolonged increase in intracellular calcium in vanilloid-sensitive neurons, while leaving other, adjacent neurons unaffected.”
Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control.“… RTX significantly upregulated phagocytosis (p < 0.05), markedly … release of IL-1β (p < 0.01), ifCa2+ , hydrogen peroxide (H2O2), and slightly downregulated the Nitric Oxide Synthase (NOS) activity, NOS activity-to-arginase activity … levels of Lactate Dehydrogenase (LDH)-based cytotoxicity, and the production of IL-6 and IFN-γ.”
“The data demonstrate that VR1 receptor agonists capsaicin and resiniferatoxin lead to a sustained increase in intracellular calcium and sodium in a concentration-dependent manner, followed by cell death.”
“Capsaicin analogs capsazepine and resiniferatoxin also produce inhibition of CCE via block of I(CRAC).”
“Several members of the RTX family of toxins, including ACT, have been shown to induce intracellular calcium increases, through different mechanisms.”
Bordetella Adenylate Cyclase Toxin Promotes Calcium Entry into Both CD11b+ and CD11b− Cells through cAMP-dependent L-type-like Calcium Channels*“ Resiniferatoxin also caused … a Ca2+‐ and lipid‐dependent kinase (or kinases) in the cytosolic fraction of dorsal root ganglia, at concentrations (100 nM to 10 µM) higher … displacement of [3H]resiniferatoxin binding or translocation of protein kinase C. Capsaicin (up to 10 µM) was unable to mimic this effect.”
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