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Last Updated: 2 years ago

Possible Interaction: Reserpine and Ebselen

supplement:

Ebselen

Research Papers that Mention the Interaction

In the present investigation, the authors examined whether ebselen , an antioxidant organochalcogen with glutathione peroxidase-like activity, changes the behavioral and neurochemical effect of acute reserpine administration.
Reserpine injection for 3 days every other day caused a significant increase on the tongue protrusion frequency and ebselen (30 mg/kg ip for 4 days, starting 1 day before reserpine) reversed partially the effect of reserpine (P<.05).
Reserpine- and reserpine+ebselen-treated groups displayed an increase in vacuous chewing frequency when compared to control and ebselen-treated groups (P<.05) Reserpine increased the duration of facial twitching and ebselen reversed partially the effect of reserpine (P<.01).
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2003  |  View Paper