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Last Updated: 2 years ago

Possible Interaction: Reserpine and Digitalis

supplement:

Digitalis

Research Papers that Mention the Interaction

Apparently the time sequence of doses of reserpine and digitalis alters the results.
Cases of "alarming cardiac arrhythmias" were reported following simultaneous administration of digitalis and reserpine.
The Annals of pharmacotherapy  •  2006  |  View Paper
Reserpine can increase gastric acidity, induce mental depression, and when used with digitalis lead to ventricular premature beats.
Canadian Medical Association journal  •  1962  |  View Paper
From these various reports, it would appear that although reserpine may increase the possibility of arrhythmias induced by digitalis glycosides it also decreases lethal potential of the glycosides.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1967  |  View Paper
After 5 mg/kg of reserpine , the dose of all digitalis materials , except digoxin, needed to induce VSA was increased.
Differences in the capacity of digitalis materials to produce rhythm disturbances appeared after pretreatment with reserpine.
The Journal of pharmacology and experimental therapeutics  •  1967  |  View Paper
However, it appears that prior reserpine treatment may interfere with the inotropic response to digitalis by a mechanism other than norepinephrine depletion.
Circulation research  •  1966  |  View Paper
Our purpose is to describe patients with alarming cardiac arrhythmias which appeared following the simultaneous administration of digitalis and reserpine.
Archives of internal medicine  •  1962  |  View Paper