Possible Interaction: Reserpine and Calcium Supplement

“In the parotid gland, reserpine and isoproterenol cause a decrease of the calcium concentration in acinar cells, due to a lower calcium content of the zymogen granules.”

“ Reserpine , isoproterenol, and pilocarpine cause an increase in the calcium concentration in submandibular gland acinar cells, due to an increased calcium content of the intracellular mucus.”

“The calcium induced increase in ATPase and the rate of calcium uptake of the vesicular fragments of sarcoplasmic reticulum isolated from rabbit skeletal muscle are reduced by reserpine , prenylamine, chlorpromazine and imipramine.”

“ Calcium concentration of the submaxillary (SM) gland of adult rat was increased to …-3 times control levels 24 h after a single high dose of reserpine (RES) (5 mg/kg body weight), 6-hydroxydopamine (6-OHDA) (20 mg/… body weight), or surgical removal of a superior cervical ganglion (Sx).”

“ Calcium prevents the depletion of catecholamies from the glomus cells by reserpine.”

“ Calcium contents were significantly decreased by 4 mg/kg reserpine , while magnesium contents were increased by 1 and 4 mg/kg.”

“Animals that have been treated with reserpine have been found to have a transient decrease in the calcium content of their vascular tissue.”

“The calcium content also fell after 10 days' administration of reserpine in daily doses of 0.1 mg/kg b.w.”

“ Tissue calcium content of the aortae of the groups which received reserpine , the two reserpine analogues and 1.0 mg guanethidine/kg/day was significantly lower than that of normal rabbits or the 2 % cholesterol group.”

“ Reserpine and prenylamine (each 6 × 10−5 M) inhibited the ATP-Mg++-dependent uptake of noradrenaline by the vesicles as well as the Ca++ and Mg++ stimulated ATPase.”

“The effect of reserpine was diminished in calcium free medium , but that of tyramine was not affected in calcium free medium.”