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Discover Supplement-Drug Interactions

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Last Updated: 4 years ago

Possible Interaction: Recombinant Human Bone Morphogenetic Protein-2 and Calcium Supplement

Research Papers that Mention the Interaction

The rhBMP-2 significantly increased the calcium content, phosphonium content, and ALP, type I collagen, and OCN mRNA levels of rASCs cultured on beta-TCP.
Tissue engineering. Part A  •  2010  |  View Paper
rhBMP-2 significantly increased the OCN and phosphate content, mineral formation, ALP activity, osteogenic biomarkers OCN, and Runx2, and decreased calcium content in hAMSCs seeded on the nHAC/PLA scaffold.
International journal of molecular sciences  •  2018  |  View Paper
The process is notably influenced by adding calcium or phosphate to the system but, while calcium ions increase the adsorption of rhBMP-2 m onto HA, phosphate ions inhibit it.
Journal of inorganic biochemistry  •  2005  |  View Paper
Low concentration of Ca2+ ( 0.18 mM) enhanced rhBMP-2-induced osteogenic differentiation, while high Ca2+ concentration (>1.80 mM) exerted negative effect.
Scientific reports  •  2015  |  View Paper