Possible Interaction: Rabbit Allergenic Extract and Adrenocorticotropic Hormone

“Thus, ACTH increases the impulse-evoked noradrenaline (NA) release in the rabbit pulmonary artery by activating presynaptic ACTH receptors, and an adenylate cyclase may be involved in this effect.”

“In the rabbit the hypercitricemia observed upon ACTH administration is accompained by a severe hypocalcemia and drop in blood pressure, resluting in tetanic convulsions.”

“Insulin, adrenaline, ACTH , and glucagon lower potassium levels in the rabbit.”

“Large doses of adrenocorticotrophic hormone ACTH ) and cortisone have been shown to produce a depression of thyroid function in the rabbit as judged by their effect on the rate of release of thyroidal radio-iodine, a very direct index of thyroid activity (Brown-Grant, Harris & Reichlin, 1954b).”

“The data show that ACTH is acting at both transcriptional and post-transcriptional loci to increase the amount of rabbit adrenal P450c17 and that the greater effect is post-transcriptional.”

“It is concluded that ACTH exerts two primary effects on the cardiovascular system of the rabbit : presynaptic facilitation of the noradrenaline release and postsynaptic vasodilation.”

“DCS and ACTH causes an increasing cellular proliferation in the arterial wall of the rabbit.”

“In a medium containing 7.6 mEq/l of Mg++ and no Ca++, ACTH at 0.1 mug/ml or more stimulated adenylate cyclase activity in both rabbit and rat adipose homogenates by 6- to 12-fold.”

“An increased permeability of the blood-aqueous barrier in the rabbit eye has been reported after systemic administration of corticotropin (1).”