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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quinine
drug:
Troleandomycin
Research Papers that Mention the Interaction
“Ketoconazole and troleandomycin inhibited the 3-hydroxylation of quinine in all species.”
The In vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes.“When the plasma/serum concentrations possibly attained after their usual therapeutic doses were taken into account, tetracycline, doxycycline, omeprazole, ketoconazole, nifedipine, troleandomycin and erythromycin are likely to be inhibitors of quinine metabolism in patients when these drugs are co-administrated with quinine.”
“Two inhibitors of CYP3A4, ketoconazole (1 microM) and troleandomycin (100 microM), inhibited quinine 3-hydroxylation by about 90% and 80%, and etoposide 3'-demethylation by about 75% and 65%, respectively.”
“ Quinine 3-hydroxylation was inhibited by the specific CYP3A inhibitors, troleandomycin , midazolam and erythromycin.”
“Ketoconazole … troleandomycin (inhibitors of CYP3A4) inhibited … 3-hydroxylation of quinine by human liver microsomes with respective mean IC50 values of 0.026 microM and 28.9 microM. Anti-CYP3A antibodies … inhibited quinine 3-hydroxylation, whereas weak inhibition was observed in the presence of S-mephenytoin or anti-CYP2C antibodies.”
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