Possible Interaction: Quinine and Tetracycline

“Cure rates for the two groups were 94% (44/47) for mefloquine plus tetracycline and 98% (45/46) for quinine plus tetracycline.”

“However, this does not seem to be the case and in fact they reduce the absorption of quinine and tetracycline (Hurwitz, 1974; Barr et al., 197]).”

“These clinical reports confirm the necessity to combine quinine with tetracycline in this area, as recommended by the recent French regional antimalarial policy.”

“Plasmodium falciparum gametocytes are persistent and infected mosquitoes for up to 21 days after patients were treated with quinine plus tetracycline.”

“The combination of quinine and tetracycline has improved the cure rate to 95-100%.”

“The results from the present study suggest that tetracycline has influence on the maintenance of plasma quinine levels above MIC throughout the treatment period.”

“Twenty-two adult males were included in an in-vivo test of the sensitivity of P. falciparum to quinine plus tetracycline.”

“Eventual clinical and laboratory-proven cure was only obtained in 1 case after combined quinine and tetracycline therapy.”

“When the plasma/serum concentrations possibly attained after their usual therapeutic doses were taken into account, tetracycline , doxycycline, omeprazole, ketoconazole, nifedipine, troleandomycin and erythromycin are likely to be inhibitors of quinine metabolism in patients when these drugs are co-administrated with quinine.”

“We used quinine alone in 126 patients, quinine plus sulfadoxine and pyrimethamine in 119 patients and quinine plus tetracycline in 239 patients.”

“Eventually clinical and laboratory-proven cure was obtained only after combined quinine and tetracycline therapy.”